Newsletter | January 4, 2024

01.04.24 -- Moving Beyond AAV: The Next Generation Of Vectors In CGT

FEATURED EDITORIAL

Moving Beyond AAV: The Next Generation Of Vectors In CGT

Dr. Konstantin Konstantinov, CTO at Ring Therapeutics, and Ryan Crisman, Ph.D., cofounder and CTO at Umoja Biopharma, share their thoughts with Cell & Gene's Chief Editor Erin Harris on the future of new anellovirus vectors and existing lentiviral vector technology for in vivo gene delivery, respectively.

INDUSTRY INSIGHTS

Improve Your AAV Manufacturing Process

Meet the demand for AAV-based gene therapies by using design-of-experiment and fit-for-purpose plasmids and transfection reagents.

MAM Solutions For Process, Product Control Of Biotherapeutic Proteins

With industry-leading scientific expertise and customer support, we have pioneered solutions to some of the most pressing challenges facing customers interested in adopting MAM into their organizations.

The Impact Of Processing Speed In Cell Separation Outcomes

Cell separation techniques enable protein purification and the removal of contaminants. Explore how the processing speed of cell separation can impact quality, process efficiency, and overall economics.

4 Factors To Consider When Scaling Up

It's essential to understand how scaling up is affecting your aseptic filling operations. Here are four topics to consider to help ensure your drug product will be taken care of and ready for production.

The Importance Of Scalability In Viral Vectors

Diseases that lack a cure, or even treatment, may be addressed with new gene therapeutic classes. This potential has spurred new investments in the drug development and commercialization space.

Understand Total Cost Of Ownership For Cleanroom Modality Decisions

Are you seeking guidance to evaluate cleanroom design/built parameters? Utilize this guide to better understand the total cost of ownership and how to perform a fast and effective cost-benefit analysis.

Choose The Right Bioreactor Size For Your Cell Expansion

Compare expansion parameters when adherent cells are cultured on the small and standard bioreactors using a hollow-fiber bioreactor platform.

Gene-Edited CAR T Cells For Off-The-Shelf Cancer Therapy

Access this report where the use of a novel lipid nanoparticle (LNP) reagent in a validated protocol was used to achieve gene editing in primary T cells with high efficiency while maintaining high cell viability.

Bridging The Distance To Large-Scale GMP Manufacturing Of Viral Vectors

AGC Biologics discusses its journey to the successful implementation of iCELLis bioreactors in their AAV and lentivirus platforms.

Discovery To Clinic: CRISPR-Based Therapies And Diagnostics

As CRISPR use continues to grow, so has the demand for clinical-grade guide RNA. Learn about GMP sgRNA and their stringent process and manufacturing controls.

SPONSOR

Cell & Gene Live welcomes Dr. Peter Marks, director, CBER, FDA, and Dr. Nicole Verdun, super office director, CBER, FDA, to discuss the evolving regulatory landscape in 2024 for cell and gene therapies. Join this interactive discussion as we cover improved communication with sponsors, increased speed availability through manufacturing processes and standards development, and much more. Registration is free thanks to the support of Thermo Fisher Scientific.

SOLUTIONS

Selecting The Best Biotinylated Proteins To Optimize Your Assay

Serum-Free, Animal Component-Free, And Protein-Free Cold Storage Solution

Chemically Defined, Safe, And Effective Cryopreservation

Biopharmaceutical Process & Manufacturing Technology Services

Biomarkers To Eliminate The Hassles Of Cell Line Control

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