Newsletter | November 19, 2024

11.19.24 -- How Ring's Single-capsid Protein Approach Optimizes Viral Delivery

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Strategies for the Separation and Analysis of Empty and Filled Capsids During Viral Vector Production

There are challenges in AAV empty-full separation in the gene therapy industry as well as some misconceptions. Experts are always looking for ways to find the best solution to these challenges. Discover the strategies of AAV capture and empty-full separation, as well as the trends driving innovation in this area. Learn more here.

FOCUS ON MANUFACTURING

How Ring's Single-Capsid Protein Approach Optimizes Viral Delivery

Complexity and manufacturability have an inverse relationship. Ring’s platform seeks to simplify highly complex gene therapy production by making the most of biology.

Laminar Flow Hoods In The Pharmaceutical And Compounding Industries

Here, we compare and contrast horizontal and vertical airflow hoods and discuss their applications and benefits in the pharmaceutical and compounding industries.

What Is Transfection?

Learn about the process of transfection and why it is crucial for studying gene function and has applications in various fields, including drug development and gene therapy.

Safer Single-Use Materials To Enhance Advanced Therapy Manufacturing

Single-use tech suppliers must align with advanced therapy manufacturers to de-risk manufacturing processes and chemical composition requirements to maintain the safety and efficacy of new treatments.

Accelerating Lentivirus Manufacturing: Choosing The Right Platform

Watch to hear from industry experts on how to streamline and ensure the success of lentiviral-based therapies, from process development through to market approval.

Optimizing mAb Production: Temperature And Osmolality's Impact

Explore the effects of simultaneously adjusting temperature and osmolality on the generation of host cell proteins (HCPs), antibody yield, and cell growth.

Options And Challenges In Subvisible Particulate Contamination Monitoring

This presentation emphasizes the significance of minimizing particulate contamination in pharmaceutical and biopharmaceutical products produced through the use of single-use systems.

Ancillary System Integration For Closed Cell Therapy Manufacturing

The material and packaging requirements for CGT are undoubtedly unique. Uncover how platforms are being established to support the specific needs of this industry. 

Elevating AAV Manufacturing With Tailored Cell Lines

Skillfully crafted cell lines can substantially enhance vector purity and yield. Watch to explore a portfolio of engineered cell lines and their potential to transform the landscape of AAV production.

Choose The Right Bioreactor Size For Your Cell Expansion

Compare expansion parameters when adherent cells are cultured on the small and standard bioreactors using a hollow-fiber bioreactor platform.

Optimizing Washing Efficiency In Cell Washing And Media Exchange

Review data collected on the performance of a single-use centrifuge in cell washing that demonstrates how it can help cell therapy manufacturers using a closed system.

A New Tool For Rapid Analysis Of Large Viral Vectors

Optimize your viral vector characterization with an instrument that features a semiautomatic workflow, enabling you to analyze samples of adenovirus and lentivirus within minutes.

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Despite significant advances, challenges remain in optimizing AAV-based treatments for broader clinical application. Join Cell & Gene Live on December 10th for a discussion on the latest developments in AAV vector design, manufacturing processes, and clinical strategies as well as key issues such as immunogenicity and regulatory considerations that are shaping the future of AAV gene therapies. Registration is free thanks to the support of Roche CustomBiotech.

MANUFACTURING SOLUTIONS

Aseptic Micro-Connector For Cryogenic Freezing Applications - CPC

CRISPR From Research To Therapy - Lonza

Pharmaceutical Aseptic Filling Equipment - AST

Cryopreservation Media: NB-KUL 10 - Nucleus Biologics

A Comprehensive Upstream Platform For Gene Therapy Applications - Cytiva

Automated Maxiprep Plasmid Purification - Thermo Fisher Scientific

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Webinar: Successful Scale-Up Of An Upstream Viral Vector Process Using An Adherent Platform

The complexity of scaling viral vector processes to commercial levels and the absence of standardized approaches poses significant challenges for therapy development timelines and productivity. See how choosing the right production platform can help you achieve commercial timelines and manage costs. Learn how to achieve versatility with a scalable, single-use end-to-end platform and optimize small-scale expression systems into a scalable process.

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