Newsletter | February 18, 2025

02.18.25 -- Host Cell DNA Impurities: A Unique Challenge For rAAV

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Join Cell & Gene Live for an exclusive look at cutting-edge manufacturing technologies revolutionizing cell therapy production. Our expert panel will explore organoids, 3D cultures, automation, and scalable solutions to streamline processes and enhance efficiency. Gain insights into the latest innovations driving the future of cell therapy. Registration is free thanks to the support of CPC and MaxCyte.

FOCUS ON MANUFACTURING

Host Cell DNA Impurities: A Unique Challenge For rAAV

The potential safety impact of residual hcDNA remains largely unknown, but researchers at UCB are investigating to learn more and mitigate if necessary.

TFDF-Based Intensified Virus Production

Learn how Tangential Flow Depth Filtration (TFDF) enhances viral vector production, streamlining the clarification process and increasing efficiency and yield for LV and AAV manufacturing.

Key Factors For Successful Plasmid Production

Review the distinct steps in the plasmid production workflow, along with tips for optimization from vector and strain selection to cultivation and beyond.

Ways To Enhance Access To Cell Therapies

Cell therapies are revolutionizing cancer care, but their complex manufacturing and high costs bar access for many patients. Automation is emerging as an efficacious solution to reach patients in need.

A Scalable Single-Use Two-Step pDNA Purification Process

Evaluate the performance of a single-use two-step plasmid purification process, and see how it compares to the existing three-step purification method.

Transforming T Cell Manufacturing Via Elutriation With Korus

Learn about a system that uses a gentle elutriation process to give manufacturers a cleaner cell population to begin cell therapy production processes such as CAR-T.

PTFE Containment: Viable For Temperature-Sensitive Protection

See why single-use cold-chain containers made with polytetrafluoroethylene fluoropolymers may be less susceptible to failure and breakage at cold temperatures.

Best Aseptic Practices For The Future Of Cell And Gene Therapies

Explore best aseptic practices for cell and gene therapy production that will be foundational to the ongoing development of these therapies as well as their successful manufacturing operations.

How To Achieve Right-First-Time Manufacturing

Discover the best way to successfully modernize QC laboratories.

Accelerating CGT Development

The EXCiPACT certification for Excipient GMP quality media and buffers ensures the safety, efficacy, and scalability of cell and gene therapies, accelerating development and improving patient access.

MANUFACTURING SOLUTIONS

FectoVIR-LV Transfection Reagent - Sartorius

MicroCNX Series Connectors: Introducing The MicroCNX ULT And MicroCNX Luer - CPC

Benchtop Macro Mass Photometer: KaritroMP - Refeyn

Pharmaceutical Laminar Flow Equipment For Cleanrooms - AES Clean Technology, Inc.

RoosterBio Process Development Services - RoosterBio

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