Case Study

Hospital Researchers Turn To Corning To Help Scale Up Ex Vvivo Expansion Of Adipose Stem Cells

Breast Cancer pink ribbon iStock-897593850

Copenhagen University Hospital researchers turn to Corning for help scaling up ex vivo expansion of adipose stem cells to test the effect and reliability of a new procedure for breast reconstruction.

Autologous fat grafting is the least invasive method for breast reconstruction, but also has major drawbacks, including high tissue resorption rates of up to 80%. Researchers in Denmark, led by Prof. Krzysztof Drzewiecki, Department of Plastic and Reconstructive Surgery and Dr. Anne Fischer-Nielsen, Department of Clinical Immunology, Rigshospitalet, had a hypothesis: what if you could enrich the human fat graft with autologous adipose stem cells (ASCs) to increase graft survival? But they faced a major obstacle: how do you culture a sufficient volume of stem cells to increase grafting success? Dr. Peter Glovinski, leader of the present clinical study, turned to Corning, who designed a scale-up solution that’s enabling them to grow the billions of stem cells required to move forward with this clinical study.

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