Fine-Tuning Your mRNA-LNP Formulation With An Innovative Cationic Lipid Library

Lipid nanoparticles (LNPs) have shown remarkable efficiency in delivering RNA-based therapeutics in vivo. However, modulating the characteristics of nanoparticles made with conventional ionizable lipids, especially their biodistribution profile, remains a challenge. Often, these ionizable lipid-based nanoparticles primarily target the liver. A key obstacle in this area is adjusting the chemical makeup of these particles to suit specific therapeutic applications.

In this webinar, the characterization of a library of 10 innovative imidazolium-based cationic lipids as key components of cationic LNPs (cLNP) is discussed. Explore their chemical structures and their efficacy in generating LNPs through the characterization of their hydrodynamic diameters, Zeta potentials, encapsulation efficiencies, efficiency, and in vivo biodistribution.

Watch to learn how a library of novel proprietary cationic lipids, can address current challenges with mRNA therapeutics.