Newsletter | November 11, 2026

11.11.26 -- Exploring Earlier Gene Editing For Children With Dr. Haydar Frangoul

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FOCUS ON TRANSLATIONAL RESEARCH

Exploring Earlier Gene Editing For Children With Dr. Haydar Frangoul

In Part 1 of this two-part series, Dr. Haydar Frangoul discusses early CRISPR gene editing with exa-cel in children with sickle cell disease and beta thalassemia.

Unlocking MSC-EV Quality: Why Tissue And Donor Variability Matter

Tissue source and donor identity drive measurable differences in MSC-EV quality attributes. See how analytical profiling reveals what varies and why it matters for scalable manufacturing.

How Model-Driven Design And AI Overcome Biomanufacturing Limits

Traditional biomanufacturing relies too heavily on trial and error. By integrating AI and mechanistic models into early design, developers can overcome productivity limits and accelerate timelines.

Optimizing Transposon-Based Gene Delivery For Cell Therapy Applications

Transposons offer an efficient, cost-effective method for gene transfer in cellular engineering. Proper delivery refinement can significantly improve overall cell expansion and functional performance.

Metabolic Shift Monitoring Of Immune Cells During Differentiation

Real-time tracking of glucose and lactate kinetics reveals critical metabolic shifts during immune cell differentiation, enabling quantitative evaluation of cellular state changes.

Essential CRISPR Fundamentals: Mechanisms And Experimental Design

Gain a clear understanding of CRISPR fundamentals, from molecular mechanisms to experimental design, as well as how to improve precision and reduce off-target effects for more reliable results.

TRANSLATIONAL RESEARCH SOLUTIONS

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Advanced Digital PCR System - Bio-Rad Laboratories, Inc.

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Organ-Chip Research Kit - Emulate

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