Study Of Small Bioreactor Expansion Kinetics During Expansion Protocol Using MSCs

With the Quantum Flex® system, adherent cells can be grown on either the standard bioreactor (2.1 m2 of surface area) or the small bioreactor (approximately 0.2 m2 of surface area). Enabling automation earlier in process development allows for cost-effective, automated process development in like-for-like technology for scaling up and out.

In this study, mesenchymal stem cells (MSCs) were used to show equivalent expansion kinetics during a 7-day expansion protocol on both the small and standard bioreactors with 99% viability. The important difference between these small and standard bioreactors, is that the small bioreactor required 73% fewer cells to seed and 80% less media for expansion.