Ex-Vivo T Cell Depletion In Allogeneic Hematopoietic Stem Cell Transplantation (HSCT): CliniMACS Prodigy® LP-TCRα/β-19-45RA System

Cell depletion strategies play a critical role in allogeneic hematopoietic stem cell transplantation, helping balance immune reconstitution with the reduction of unwanted cell populations. Flexible depletion workflows enable the selective removal of TCRα/β+ T cells, CD19+ B cells, and CD45RA+ cells—either individually or in combination—to support the generation of tailored cell products from leukapheresis material. Process automation further enhances consistency by integrating labeling, depletion, and collection steps within a closed manufacturing environment.

With support for multiple use cases and scalable processing capacities, the workflow accommodates a range of manufacturing needs while maintaining strong viability and recovery of desired cell populations. Gain insight into strategies for producing optimized graft products for transplantation and advanced cell therapy applications.