|
|
|
|
| Developing a scalable, GMP-ready AAV8 production platform is complex and requires a unified approach across upstream and downstream operations, data-driven decisions, and efficient progression from bench scale to manufacturing-relevant volumes. In this white paper, Matica Biotechnology and Sartorius demonstrate how collaboration enabled the design, optimization, and scale-up of an integrated AAV8 process to 50L with reproducible performance, sharing practical lessons in upstream optimization, downstream purification, capsid separation, and analytics to support flexible gene therapy manufacturing. |
|
|
|
|
By Juergen Metzger, Pharma-Technology-Consulting LLC | Robotics and automation have been a hot topic in CGT for their perceived benefits in preventing contamination and reaching compliance. But this is not a quick and easy solution, and this simplification ignores most of the full picture. Take a more realistic look at robotics and the role it can play in your workflow. | |
|
|
|
|
| Scale-Up AAV Production In Fixed-Bed Bioreactors | Application Note | Cytiva | Consistent AAV production is critical for manufacturing. See how aligned strategies deliver comparable cell growth, metabolic trends, and rAAV5 titers from development through production. |
|
|
| A Production Platform To Streamline Your AAV Process | White Paper | MilliporeSigma | Gene therapies offer immense promise, but scaling production introduces complex bottlenecks. Evaluate how upstream optimization enhances yield, boosts consistency, and accelerates timelines. |
|
|
|
|
|
| Applying Intensified Perfusion Strategies | Webinar | Repligen | Explore how intensified perfusion strategies enable rapid, high‑density CAR‑T expansion, predictive scale‑down modeling, and efficient automated harvest, supporting shorter timelines and higher yields. |
|
|
|
|
|
|
|
|
|
|
|
|
| Connect With Cell & Gene: |
|
|
|
