04.11.24 -- Drugging The Undruggable: Strategies And Future Directions

Single-use cold-chain containers made with polytetrafluoroethylene fluoropolymers may be less susceptible to failure and breakage at cold temperatures.

Review this demonstration where animal component-free Insti CHO and HEK cell culture supplements enable the industry to overcome cell culture limitations while meeting regulatory requirements.

There is no one-size-fits-all model for AAV gene therapy products when it comes to viral clearance studies. Here, we address some of the questions with respect to viral clearance studies for AAV vectors.

A key reason mRNA is considered a significant breakthrough is its potential to enable rapid and scalable drug development. Examine the hurdles that must be overcome to deliver on its promise.

Analyze the cost distribution over time for autologous CAR T therapy manufacturing using process economics and additional insights. Discover how cell therapy manufacturers can combat these costs.

Cleanroom systems are purposely designed to simplify implementation of the aseptic manufacturing space that the industry needs to meet future sterile injectable capacity demand.

Delve into the details of a partnership that resulted in custom-ordered synthetic T cell mimics to solve challenges with lot-to-lot variability and long-term stability.

As more T cell therapies come to market, the quality and scale of treatments are set to improve further. See how technological advances have made it possible to produce high-quality T cells at scale.

Explore the importance of understanding potency in cell and gene therapy (CGT) development and the challenges in developing potency assays for CGT products.

To run clinical studies quickly, safely, and with high data integrity, it's effective to assess trials by degree of touch. Discover how different trial types are suited to the application of different tools and methods.

AAV therapies require high quality and high titers of viral genomes per dosage, prompting the need for a more efficient AAV manufacturing method to reduce overall costs.