09.03.24 -- Developing And Manufacturing Oligonucleotides: An Overview

Explore how digitalization can significantly enhance control and accelerate processes for cell and gene therapy manufacturers, driving greater efficiency and innovation.

Single-use technology and innovative fluid connections play a significant role in creating an effective, sterile fill and finish operation that maintains the integrity of your biologic products.

Developing a combination product and seeking a list of tests to complete design verification testing? Review the details for planning, design inputs, design outputs, and design verification.

The development of mAb based therapeutics can be a time-consuming and costly process of cell line establishment, but high-throughput screening and automated methods for IgG quantification can help.

Discover the ability of a novel HEK293 suspension cell line for efficient and scalable rAAV production across various serotypes with low encapsidated host cell DNA levels.

Learn why cryopreservation studies are so critical and how biopharmaceutical manufacturers can more easily navigate the complexities of this process.

Here, we demonstrate a scalable workflow for the isolation of exosomes that combines tangential flow filtration for the concentration of exosomes followed by gentle size exclusion chromatography.

Explore approaches for the capture and separation of capsids, upstream strategies for reducing the level of empty and partially filled capsids, trends in AAV capsid design impacting purification, and more.

Proof of monoclonality is regularly a bottleneck in the cell line development workflow. Uncover an innovative piece of cell line development imaging technology.

Current advances in cell, gene, and tissue therapies require a rethinking of how—and where—cleanroom manufacturing facilities could be built, enabling more options for sponsor process control.

As cell therapies develop and become more commercialized, manufacturers must adopt a sophisticated supply chain that provides the necessary materials and technologies to support therapeutic development.