NB-ROC™ T Cell SF Media

The NB-ROC™ Advantage

• Boost Transduction Efficiency

Yield more CAR+ cells at lower viral MOI to maximize the number of CAR+ cells in your therapeutic dose, which has shown to improve outcomes.

• Lower Manufacturing Cost

Decrease the amount of viral vector used in your CAR-T process, which can result in reduced cost and increased safety of the final therapeutic dose.

• Maintain Key Quality Indicators

Promotes proliferation and population doubling, and maintains desired phenotypes and all other quality indicators, like cell health and viability.

Maximize T Cell Performance

The right media can ease development challenges and impact speed, cost, and quality of the therapeutic dose. NB-ROC is optimized for CAR-T cell therapy development, primarily focused on significantly improving transduction, while maintaining all other critical attributes.

Significantly Improves Transduction Efficiency

Combining NB-ROC with 2% Physiologix (NP), a serum-free complete media, improves transduction efficiency when compared to OpTmizer™ + 5% Human Serum (OH) and OpTmizer + 2% Physiologix (OP). Data shown represents average of 3 donors ±SD in a G-Rex® model.

Promotes Strong T Cell Growth

NB-ROC + 2% Physiologix (NP) supports strong population doubling equivalent to OpTmizer™ + 5% Human Serum (OH) and OpTmizer + 2% Physiologix (OP). Proliferation, cell health, viability, and maintenance of relevant phenotypes (assessed but not shown) are also comparable. Data shown represents average of 3 donors ±SD in a G-Rex® model.

Increases CAR+ Cells in Your Therapeutic Dose

NB-ROC increases efficacious cells in your process. Using GFP as a marker of lentiviral transduction, NB-ROC + 2% Physiologix (NP) shows significantly higher numbers of transfected cells compared to OpTmizer™ + 5% Human Serum (OH) and OpTmizer + 2% Physiologix (OP) after 7 days of culture. Data shown represents average of 3 donors ±SD in a G-Rex® model.

Specifications