Criteria For Effective Bioprocess Scale-Up With The DynaDrive Single-Use Bioreactor

At every stage of biologics development, scaling presents the same core challenge: the physical environment inside a bioreactor changes fundamentally as volume increases. Mixing behavior, oxygen transfer, and fluid dynamics do not scale proportionally, and the conditions that sustain a healthy, productive culture at bench scale cannot simply be carried forward to production. Knowing which parameters to prioritize, and how to balance competing tradeoffs, is what determines whether a technology transfer succeeds or stalls.

This white paper walks through the four cornerstone scaling criteria: mixing time, tip speed, power input per volume (P/V), and oxygen transfer coefficient (kLa). It unpacks the engineering principles behind each and the scenarios where they perform best. Crucially, it also explores why no single parameter tells the whole story, and how bulk averages can mask localized conditions that affect cell health and product quality. Download the white paper to learn more.