Cas9 mRNA: Wild Type And Spy Fi High-Fidelity Formats For Research Grade CRISPR Applications

As genome editing programs move from early research toward therapeutic development, researchers need Cas9 mRNA that delivers strong editing performance while supporting evolving workflow and scale requirements. Aldevron Cas9 mRNA is available in wild-type and SpyFi™ high-fidelity formats, offering high on-target editing efficiency with options designed to reduce off-target activity.

Research-grade formats support multiple delivery approaches, including LNP, cationic lipid, and electroporation, while off-the-shelf and custom options provide flexibility as programs advance. Performance data in T cells demonstrate editing across clinically relevant targets and compare on- and off-target activity among Cas9 mRNA formats. With cGMP manufacturing also available on request, researchers can plan for future development needs.

Explore the data, technical specifications, available formats, and delivery considerations for selecting Cas9 mRNA for your genome editing workflow.