Newsletter | February 1, 2024

02.01.24 -- Breaking Down Solid Tumors

SPONSOR

With recent news spotlighting next generation RNAs (e.g., Circular Genomics raising $8.3 million for their circular RNA-based clinical assays), we are delighted to bring the community together in May for the 3rd Next Generation RNA Therapeutics Summit, the industry’s only forum solely dedicated to advancing circular, self-amplifying, and next generation RNAs. Find out more

FEATURED EDITORIAL

Triumvira Immunologics' Dr. Paul Lammers Breaks Down Solid Tumors

Paul Lammers, MD, M.Sc., CEO of Triumvira Immunologics, joins Cell & Gene: The Podcast to talk to Host Erin Harris about TAC, the company's proprietary T cell antigen coupler, which has both autologous and allogeneic approaches. They also discuss targeting relapsed or refractory HER2-positive solid tumors and CLDN18.2-positive solid tumors.

INDUSTRY INSIGHTS

Bringing Allogeneic Cell Therapy To Patient Care

To support the treatment options and increasing scale of the industry, flexible, closed, and automated solutions will be necessary when bringing allogeneic cell therapy to patient care.

Cost Efficient Manufacturing Of Purer AAV Gene Therapy Vectors

Review a comparison of the cation exchange and affinity column for the first column step and learn how the new CIMmultus High Reproducibility (HR) line columns are used for the polishing step.

Characterize Your Viral Vectors From Discovery To GMP Release

Simplify your workflow and achieve successful protein analysis with a faster, more robust, and highly reproducible alternative method to SDS-PAGE.

Take Your CAR NK Cell Research To The Next Level

Explore a comprehensive translational workflow that includes all the tools essential for elevating your CAR NK cell research and advancing your CAR NK cells to the next level.

Integration Of Quality Management And Manufacturing Automation Systems

Quality by design (QbD) is enormously valuable but often underutilized, siloed, and not operationalized. Discover the benefits of enabling QbD with AI-driven quality operations and batch automation.

Reduce Contamination Risks When Storing Synthetic DNA

An alternative to traditional polyethylene bags is offering cell and gene therapy manufacturers a solution to contamination concerns regarding DNA or RNA fragments.

The Role Of CRISPR Cas9 Plasmids In Gene-Editing

Plasmids are crucial for CRISPR-Cas9 gene-editing technology and their role is expected to evolve with ongoing research, likely reducing the current limitations, and offering more control and precision.

Avoid Costly Mistakes In Gene Therapy Process Development

Success in the gene therapy space requires navigating uncertainties related to the process development and manufacturing of AAV and lentivirus vectors. Use these tips when operating within short timelines.

Meeting GMP Requirements For Allogeneic Cell Therapies

Learn why failure to include at least some elements of GMP in your cell line design and development process could make it more difficult to get the data required for future IND or BLAs.

SOLUTIONS

Next-Generation GMP Facility For CRISPR Based Therapies

Stainless-Steel Centrifuges For Advanced Therapy Manufacturing

Single-Use Manifolds For Operational Efficiency

The Korus System

Wipes For Critical Environments

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