Application Note

Aramus™ Single-use Bags Compatibility With Dimethyl Sulfoxide (DMSO)

Aramus Single-Use 2D Bag Assemblies

Entegris customers have asked about chemical compatibility of Aramus™ assemblies with dimethyl sulfoxide (DMSO), which is commonly used as a cryopreservant in the cell and gene therapy (CGT) markets.

The objective of this test was to determine chemical compatibility of the Aramus bag material via mechanical testing (burst and tensile strength) after exposure to 100% DMSO after different lengths of time (T = 0 (control), 24 hours, 7 days, and 21 days) at room temperature.

Aramus 50 mL (SU-2D-0.050S1-L12B) bags were tested for mechanical properties (burst and tensile strength) both before and after exposure to 100% DMSO. All bags were exposed to 42 kGy gamma irradiation prior to beginning the test.

Based on the results of the test, it appears that Aramus bag integrity was not significantly affected by exposure of 100% DMSO up to 21 days. In addition to tensile and burst data, it should also be noted that visual inspection yielded no discoloration after exposure to 100% DMSO after 21 days.

Future testing would most likely include larger sample sizes, and perhaps longer-term storage.

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