Advances In Custom Medium Development The Multi-Omics Difference

Spent media analysis has long played a critical role in media development workflows, offering valuable insights into cellular metabolism and nutrient consumption. As bioprocessing technologies evolve, traditional methods are being complemented — and in some cases enhanced — by advanced analytical techniques that offer deeper and more comprehensive data. Among these, multi-omics approaches are gaining significant traction within the scientific and biomanufacturing communities.

In this context, multi-omics refers to the integrated use of proteomics and metabolomics to build a more holistic view of cellular function. Proteomics involves the large-scale study of proteins expressed by cells, particularly those involved in intracellular signaling and metabolic pathways. Metabolomics, on the other hand, focuses on the small-molecule metabolites that are the end products or intermediates of these pathways. By combining these two disciplines, researchers can gain a more detailed understanding of cell physiology, media interactions, and process optimization opportunities, ultimately leading to more efficient and predictive media development strategies.