ABOUT BERKELEY LIGHTS

Berkeley Lights is a leading Digital Cell Biology company focused on enabling and accelerating the rapid development and commercialization of biotherapeutics and other cell-based products for our customers. The Berkeley Lights Platform captures deep phenotypic, functional and genotypic information for thousands of single cells in parallel and can also deliver the live biology customers desire in the form of the best cells.

APPLICATION NOTES

VIDEOS

CONTACT INFORMATION

Berkeley Lights

5858 Horton St, Suite 320

Emeryville, CA 94608

UNITED STATES

Phone: 510-585-2855

BROCHURES

  • Learn about an Optofluidic System that enables rapid selection of lead molecules by function-forward screening of B cells from immunized animals in under 1 week.

  • The Opto Plasma B Discovery 4.0 workflow on the Beacon® optofluidic system enables functional profiling of the B cell repertoire to rapidly advance lead molecules against difficult targets.

  • Explore how this optofluidic system offers an integrated end-to-end automated workflow for rapid cloning and selection in mammalian cell line development.

  • Our T cell workflow allows you to investigate complex cell-cell interactions. Our portfolio of capabilities includes assays to study polyfunctionality, cytotoxicity and the ability to directly link phenotype to gene expression.

  • The Opto™ Cell Therapy Development worfklow accelerates the creation of better therapeutics by enabling multiple functional assays to be performed simultaneously on 1000s of individual T cells in a matter of days. Deeply characterize, profile, and map your T cell populations at the single-cell level to directly link behavior to gene expression.

  • Find out how the Opto™ Cell Line Development workflow sets a new standard for quality, capacity, and speed in cell line development to let BioPharma get more molecules to the clinic faster.

  • Identifying T cell functional signatures is a long, laborious, and complex process that requires you to draw conclusions from surrogate measurements collected on multiple platforms. The Lightning system changes this by allowing you to directly visualize the phenotype and function of 1000s of individual cells in just days and recover cells of interest alive. 

  • Find out how the Opto™ Cell Line Development  workflow sets a new standard for quality, capacity, and speed in cell line development and allows CDMOs to scale operations and drive new business.

  • Antigen-specific T cells can be selectively expanded using the Opto™ Antigen Presenting Bead kit upstream of the Opto™ Cell Therapy Development workflow, enabling you to directly link peptide binding and recognition to antigen specific effector function.

  • Cytokine assays in the Opto™ Cell Therapy Development workflow allow simultaneous functional interrogation of thousands of individual T cells as they interact with antigen-presenting cells, granting insight into the heterogenous mechanisms that regulate cytokine secretion. The automated assays also allow live recovery of individual clones for downstream analysis. Cytokine assays and cell surface markers can be customized.

  • The Opto™ Cell Therapy Development workflow Cytotoxicity Assay  enables kinetic analysis of killing activity from single T cells, followed by live cell recovery for genomic analysis. This assay avoids common problems associated with traditional killing assays, which measure average target cell lysis at fixed time points, obscuring kinetic details and ignoring the heterogeneity present in T cell subsets.

  • Identifying T cell functional signatures is a long, laborious, and complex process that requires you to draw conclusions from surrogate measurements collected on multiple platforms. The Lightning system changes this by allowing you to directly visualize the phenotype and function of 1000s of individual cells in just days and recover cells of interest alive.

  • Used downstream of functional T cell assays in the Opto™ Cell Therapy Development workflows, the TCRseq kit enables recovery of functionally validated T cell receptors (TCRs) from fewer than 10,000 input cells. Instead of re-expressing hundreds of TCRs in the hopes of identifying the rare sequence that imparts ideal specificity, the kit allows users to only sequence the T cells that matter.