FEATURED ARTICLES

• Validation Of ICON™ Automated Cell Counting And Viability Assay

  Explore this study aimed at validating ICON’s Viability Assay by measuring cell samples with a range of expected concentrations and viabilities.

• A Perspective On Various Use Cases Of Osmolality In Quality Control

  Learn how osmolality testing provides quick and easy identification of where certain solutions may be deviating from specification in the biomanufacturing sector of the clinical market.

• Assurance Of Clonality For Biotherapeutics

  The clonality of Master Cell Banks (MCBs) for production cell lines is a key requirement in biotherapeutics manufacturing. Learn how new devices help optimize the cloning process.

• Pharma & Biotech: How Labs Achieve Data Integrity

  Learn from an industry expert how important it is for companies to be compliant with data integrity and to ensure the trustworthiness and reliability of electronic records.

• Automated High-Throughput Osmolality Testing With Precision And Accuracy

  Maintain confidence in decision making early in the bioprocess to ensure a safe and effective drug product further down the line.

• Osmolality Monitoring For UF/DF And CEX Capture Of mAbs

  The goal of this study was to understand the impact of monitoring osmolality during an ultrafiltration/diafiltration (UF/DF) step prior to CEX capture of the monoclonal antibody Rituximab.

• Osmolality: A Powerful Tool In Bioprocessing

  Learn more about the broad range of applications for osmolality testing and why it is crucial for process development, analytical development, and GMP testing.

• Produce A Monoclonal Cell Line Expressing A Clinical Candidate Bi-Specific Antibody In Less Time

  Explore how implementing a platform that helped a biopharmaceutical company save 6-8 weeks of work whilst still meeting the regulatory requirements. 

• A Simple Solution Slashes Cell Line Development At A Biotech Company

  A biotech company's cell line development team decided to optimize their processes and look for new equipment that could isolate single cells and speed up development. 

• Successfully Filing An IND Using Single Cell Cloning System

  Dr. Andy Tsun, co-founder and VP of Discovery Biology at Biotheus Inc, shares his company's experience using an accelerated workflow for single-cell cloning including how it helped them obtain an IND. 

• Doubling The Speed Of Cell Line Development In A Large Pharmaceutical Company

  We explore how the Cell Line Development group at Janssen R&D was able to reduce one of their development processes to a single step thanks to new technology. 

• FACS Bulk Enrichment In Combination With Cell Cloning Systems Delivers Significant Savings For A CDMO

  Learn how the Cell Line Development (CLD) department at Celonic Ag was able to optimize their workflow with new technology geared towards shortening time lines and lightening workload. 

   

• Reliable Osmolality Testing Of High Concentration mAb Formulations

  Osmolality testing has several bioprocessing applications, and new use cases are constantly emerging. This paper evaluates two osmometers for measuring concentrated protein formulations. 

• Improving Titer, Quality, And Efficiency Of AAV Manufacturing

  This study provides preliminary evidence for impact on overall yield, and quality of the AAV due to a timed osmolality shift with and without a feeding step.

• Accurate, Low-Volume, Rapid Automated Cell Counting And Viability

  We will outline the importance of accuracy and efficiency when cell counting and outline how the viability assay on the ICON can enhance your current processes.

• Enhance Your Cell Line Development Process To Provide Consistent Data Driven Accelerated Workflows

  We outline how the range of technologies support single-cell seeding, image based clonality assurance and allow for informed analysis of critical, cell quality attributes.

• How STUDIUS™ Is Changing Cell Line Development

  Methodologies, utilized in CLD, include viable cell counting, confluency, single cell seeding, plate transfer and consolidation, titer assays and microscopy. It is central to this narrative that data from all these aspects are joined together in a single story of a cell’s journey through this process.

• Clonality In Stem Cell Derived Therapies

  The question of when and how to implement practices that will be scalable to cGMP often arises among emergent cell therapy companies with an eye on the future production of clinical treatments.

• Development Of A Highly Efficient, Documented Workflow For Making Clonal Cell Banks Of Gene-Edited iPSCs

  Cell therapy companies need to adopt robust workflows that are designed to best manage consistency, quality of product and meet with appropriate regulatory requirements and manufacturing best practices. We explore the effectiveness of the VIPS + MatriClone workflow for gene-edited hiPSC cells.

• High Efficiency Single Cell Cloning Of hiPSCs While Ensuring Maintenance Of Phenotype

  Reduce time and cost while most importantly maintaining the cell phenotype and genomic integrity as well as providing documented evidence of cell line clonality with viable, high efficiency single cell cloning of hiPSCs.