
ABOUT ADVANCED INSTRUMENTS
Advanced Instruments is a global provider of scientific and analytical instruments for the bioprocessing and clinical industries. For more than 65 years, the company’s innovations have helped organizations improve quality of results, achieve reliable outcomes, and increase workplace productivity. In the biopharma space, the Solentim portfolio of best-in-class imaging and single-cell deposition technologies enables the clonal isolation, outgrowth, and characterization of the highest value cells for monoclonal antibody upstream development and cell and gene therapy. Its OsmoTECH® line of micro-osmometers are built specifically to support workflows throughout every phase of bioprocessing. Similarly, clinical labs worldwide rely on Advanced Instruments’ innovative solutions for delivery of accurate and timely patient results in their clinical chemistry, microbiology and hematology labs. For more information, visit www.aicompanies.com
CONTACT INFORMATION
Advanced Instruments, Inc.
2 Technology Way
Norwood, MA 02062
UNITED STATES
Phone: (781) 320-9000
Contact: Shweta Nair
BROCHURES
- Clonal Imager With Automated Assurance
- VIPS™ PRO Verified In-Situ Plate Seeding
- STUDIUS Cell Line Development Data Management Platform
- ICON Combined Titer, VCD And Productivity Analyzer
- Next Generation Supplements - Enhancing Cell Line Development Workflows
- VIPS Updates: Product Improvements For An Increased Efficiency In Single-Cell Seeding Process
- VIPS Single Cell Seeder
- Cell Metric® Clone Imager With Assurance
- OsmoTECH® HT Automation-Friendly Plate-Based Micro-Osmometer
- OsmoTECH XT Single-Sample Micro-Osmometer From Advanced Instruments
- OsmoTECH PRO Multi-Sample Micro-Osmometer From Advanced Instruments Brochure
- OsmoTECH Single-Sample Micro-Osmometer From Advanced Instruments Brochure
FEATURED ARTICLES
-
Explore this study aimed at validating ICON’s Viability Assay by measuring cell samples with a range of expected concentrations and viabilities.
-
Learn how osmolality testing provides quick and easy identification of where certain solutions may be deviating from specification in the biomanufacturing sector of the clinical market.
-
The clonality of Master Cell Banks (MCBs) for production cell lines is a key requirement in biotherapeutics manufacturing. Learn how new devices help optimize the cloning process.
-
Learn from an industry expert how important it is for companies to be compliant with data integrity and to ensure the trustworthiness and reliability of electronic records.
-
Maintain confidence in decision making early in the bioprocess to ensure a safe and effective drug product further down the line.
-
The goal of this study was to understand the impact of monitoring osmolality during an ultrafiltration/diafiltration (UF/DF) step prior to CEX capture of the monoclonal antibody Rituximab.
-
Learn more about the broad range of applications for osmolality testing and why it is crucial for process development, analytical development, and GMP testing.
-
Explore how implementing a platform that helped a biopharmaceutical company save 6-8 weeks of work whilst still meeting the regulatory requirements.
-
A biotech company's cell line development team decided to optimize their processes and look for new equipment that could isolate single cells and speed up development.
-
Dr. Andy Tsun, co-founder and VP of Discovery Biology at Biotheus Inc, shares his company's experience using an accelerated workflow for single-cell cloning including how it helped them obtain an IND.
-
We explore how the Cell Line Development group at Janssen R&D was able to reduce one of their development processes to a single step thanks to new technology.
-
Learn how the Cell Line Development (CLD) department at Celonic Ag was able to optimize their workflow with new technology geared towards shortening time lines and lightening workload.
-
Osmolality testing has several bioprocessing applications, and new use cases are constantly emerging. This paper evaluates two osmometers for measuring concentrated protein formulations.
-
This study provides preliminary evidence for impact on overall yield, and quality of the AAV due to a timed osmolality shift with and without a feeding step.
-
We will outline the importance of accuracy and efficiency when cell counting and outline how the viability assay on the ICON can enhance your current processes.
-
We outline how the range of technologies support single-cell seeding, image based clonality assurance and allow for informed analysis of critical, cell quality attributes.
-
Methodologies, utilized in CLD, include viable cell counting, confluency, single cell seeding, plate transfer and consolidation, titer assays and microscopy. It is central to this narrative that data from all these aspects are joined together in a single story of a cell’s journey through this process.
-
The question of when and how to implement practices that will be scalable to cGMP often arises among emergent cell therapy companies with an eye on the future production of clinical treatments.
-
Cell therapy companies need to adopt robust workflows that are designed to best manage consistency, quality of product and meet with appropriate regulatory requirements and manufacturing best practices. We explore the effectiveness of the VIPS + MatriClone workflow for gene-edited hiPSC cells.
-
Reduce time and cost while most importantly maintaining the cell phenotype and genomic integrity as well as providing documented evidence of cell line clonality with viable, high efficiency single cell cloning of hiPSCs.
FEATURED PRODUCTS
- Solentim VIPS™ Enhancing Cell Line Development Workflows
- Solentim STUDIUS™ The Smartest Decision-Making Platform In Cell Line Development
- ICON™ Combined Human IgG1 Titer, VCD And Productivity Analyzer
- Solentim Cell Metric® X - Clone Imaging with Automated Assurance
- OsmoTECH® XT Single-Sample Micro-Osmometer
- OsmoTECH® PRO Multi-Sample Micro-Osmometer
- OsmoTECH® HT Automated Micro-Osmometer