Viral Vector (Lentivirus, Adeno-Associated Virus, Other) Upstream And Downstream Process Development And Optimization For Manufacturing
Source: OmniaBio
OmniaBio provides process development services for both lentiviral vectors and adeno-associated viruses. Our team has completed multiple upstream and downstream projects, and successfully scaled-up to 25 L in a stirred-tank bioreactor.
Upstream process development
- Development and optimization of upstream processes for various vectors produced by transient transfection, packaging cells and producer cells
- Adaptation or transition to suspension culturing in chemically defined, animal-derived component-free (ADCF) media
- Enabling linear scalability in single-use bioreactors
Downstream process development
- Development of fit-for-purpose downstream processes for purifying and concentrating vector
- Adoption of closed processes based on single-use, scalable technologies
- Optimization of discrete unit operations to resolve production bottleneck
- Buffer development
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