CCRM provides process development services for both lentiviral vectors and adeno-associated viruses. Our team has completed multiple upstream and downstream projects, and successfully scaled-up to 25 L in a stirred-tank bioreactor.
Upstream process development
Development and optimization of upstream processes for various vectors produced by transient transfection, packaging cells and producer cells
Adaptation or transition to suspension culturing in chemically defined, animal-derived component-free (ADCF) media
Enabling linear scalability in single-use bioreactors
Downstream process development
Development of fit-for-purpose downstream processes for purifying and concentrating vector
Adoption of closed processes based on single-use, scalable technologies
Optimization of discrete unit operations to resolve production bottleneck
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