Viral Vector (AAV, LVV, AdV, And RVV) Solutions
Source: Charles River
A robust, reliable manufacturing partner offers solutions spanning the entire development timeline. Charles River can help deliver your virus program with speed and reduced costs.
We offer viral vector CDMO solutions with facilities in the US, providing products and services from early discovery through commercialization including viral vector manufacturing, molecular cloning, and viral vector packaging in support of AAV, LVV, AdV, and RVV. Our track record in manufacturing products helps to ensure our customers’ virus programs are delivered in a cost effective and timely manner.
Available Services
- Vectors Supported
- Adeno-associated virus (AAV)
- Lentivirus (LVV)
- Adenovirus (AdV)
- Retrovirus (RVV)
Analytical Development and Qualification
- Assay transfer
- Stability studies: drug substance and drug product
- Cleaning validation
- Raw material testing
- Shipping studies
- Product characterization
- QC release testing
Process Development and Scale Up
- Development of robust and scaleable process strategies
- Media development and optimization (animal component free)
- Adaptation to suspension-based growth
- Development of closed processing systems
- Transfection efficiency optimization
- Optimization of harvest parameters (MOI and POI)
- Purification by low pressure chromatography
GMP Manufacturing
- Master cell bank and working cell bank production
- Master viral seed stock and working viral seed stock production
- Clinical manufacture of drug substance and drug product Complementary
Plasmid DNA Manufacturing
- Research grade DNA
- High Quality grade DNA
- GMP grade DNA
- Off-the-shelf HQ viral vector packaging plasmid
Project Management
- Dedicated project manager
- Cross-functional project teams
- Detailed timeline planning and milestone tracking
- Regular process updates
- Risk management
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