Vial Containment Systems For Gene Therapies: Series Summary

By Margaret A. Craig, Manager, Scientific Communications, Rui Li, Ph.D., Senior Scientist, R&D, Cryobiology, and T. Page McAndrew, Ph.D., Director, Scientific Communications

To ensure the quality and efficacy of viral-vector gene therapies, manufacturers must rigorously evaluate their chosen vial-stopper-seal containment system across its entire lifecycle, including ultra-low temperature storage and handling. Proactively understanding containment system performance, especially at these demanding conditions, can streamline development and accelerate market delivery. Comparative data indicates that CZ-based systems meet or exceed the performance of traditional glass or polypropylene options, positioning them as a strong potential candidate for gene therapy applications.