Vial Containment Systems For Gene Therapies: Recovery Of Viral Vectors

By Margaret A. Craig, Manager, Scientific Communications, Rui Li, Ph.D., Senior Scientist, R&D, Cryobiology, and T. Page McAndrew, Ph.D., Director, Scientific Communications

Vial containment systems comprising Daikyo Crystal Zenith® cyclic olefin polymer vials and elastomer stoppers with a FluroTec™ barrier film were evaluated for maintenance of virus transducability after storage at ultralow temperature (approx. -80°C). With selected lentivirus vectors, adenovirus vectors, and adeno-associated virus vectors, all vectors showed equivalent or better function compared to standard systems. These data strongly suggest general utility for preserving viral vector function.