Unravel The Complexity Of Single Cell Natural Killer Cell Cytotoxicity And ADCC Mediation

Natural killer (NK) cells are a potent component of the immune system with the potential to increase the efficacy of immunotherapies and mAb therapeutics. Nuanced regulation and population heterogeneity present challenges to fully understanding the role of these cells in various cancer treatments.

In this application note we demonstrate how the Berkeley Lights Opto™ Cell Therapy Development workflow can be used to:

• Directly measure NK cell cytotoxicity at the single-cell level
• Investigate NK cell killing mechanisms and responses to chemical treatment
• Identify NK cell populations that elicit the most robust antibody-dependent cellular cytotoxicity (ADCC) in reponse to therapeutic monoclonal antibodies