Newsletter | September 30, 2025

09.30.25 -- Unlocking Method Insights For Novel Engineered AAV Capsids

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Webinar: Achieving Flexibility In T Cell Manufacturing - Adaptation Of Standardized Processes

Join Miltenyi Bioindustry’s expert-led webinar to explore how the gold-standard T Cell Transduction (TCT) process on the CliniMACS Prodigy® platform is transforming CAR-T manufacturing. Discover scalable, standardized solutions to accelerate production while preserving potency. Gain insights into G-Rex® integration, process development support, and in-depth analysis of expansion, efficiency, exhaustion, and tumor-killing performance to advance your cell therapy programs. Click here to learn more.

FOCUS ON MANUFACTURING

Unlocking Method Insights For Novel Engineered AAV Capsids

Microfluidic platforms, such as labchip, are widely used for assessing wild type capsids. Now, engineered capsids are challenging these established workflows.

Bioprocessing And Scale Up Of HEK293 Cells For AAV Production

Address your concerns with traditional viral vector production processes by using a scalable upstream AAV production platform solution for viral gene therapies.

Success Story: Increased Productivity With Concentrated Fed-Batch

Discover how a leading biopharma company boosted flexibility and quadrupled productivity by implementing a concentrated fed-batch process in a single-use facility.

Cell Culture Process Scale-Up Challenges For PSC Manufacturing

Allogeneic cell therapies offer incredible promise, but scaling up PSC manufacturing presents unique challenges. Explore these hurdles along with solutions for consistent, high-quality production.

Exploring Viral And Non-Viral Delivery Methods For Gene Therapy Manufacturing

Choosing the right delivery system is a critical decision in gene therapy. We explore the advantages and challenges of today’s leading viral and non-viral vector technologies.

Co-Precipitation Of Metal Carbonate Templated Protein Microparticles

Explore the automated production of protein microparticles using an innovative method that offers a standardized and scalable solution for co-precipitation in biopolymer particle fabrication.

Responding To Fill-Finish And Automation Scale-Up Challenges

Behind every life-saving cell therapy is a complex manufacturing journey. Examine the critical role of automation in overcoming production challenges and ensuring quality.

Optimize Transposon Delivery In CAR T Cell Manufacturing Workflows

Learn how electroporation can be used to efficiently engineer T cells for CAR T cell manufacturing workflows with piggyBac™ transposons while maintaining high viability and cell yield.

Controlled Production Of MSC-Derived EVs In Stirred-Tank Bioreactors

Learn how stirred-tank bioreactors overcome the scalability limitations of static culture for MSC-EV production, while Raman spectroscopy provides unprecedented real-time quality monitoring during production.

Scalability: Reproducible Manufacturing Across A Multi-Unit System

A study demonstrates consistent manufacturing of T cells across a multi-unit system, with low variability in key metrics like cell expansion and transduction efficiency.

End-To-End Manufacturing Of Autologous CAR T Cell Therapies

Learn about a modular, functionally closed, end-to-end solution for the manufacture of autologous CAR T cell therapies.

MANUFACTURING SOLUTIONS

Manufacturing Solutions For Your Cell And Gene Therapy Journey - Invetech

Propelling CGTs From Concept To Commercialization - Roche CustomBiotech

Separate Solids Suspended In Liquid With An Unparalleled Centrifuge - CARR Biosystems

High-Performance UF Membrane For Precision Filtration - Cytiva

Custom DMSO-Free And Chemically-Defined Cryomedia - Nucleus Biologics

EVENTS

Advancing the Future of Cell & Gene Therapy

This 11-12 November, Cell 2025 unites 1,000+ leading experts across the CGT value chain to solve key challenges, from scalable bioprocessing and regulatory hurdles to accelerating development timelines.

 

Gain practical strategies across cell culture, therapy development, and CGT manufacturing, and hear from world-renowned leaders Bobby Gaspar (CEO, Orchard Therapeutics), Christof Von Kalle, (Director & BIH Chair, Research Clinic Luxemburg), and Dame Molly Stevens (University of Oxford). Register Now

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