Ultrafiltration/Diafiltration (UF/DF) of Adeno-Associated Viruses (AAV)

Adeno-associated virus (AAV) is one of the most common viral vectors used for gene therapies, often preferred for its safety and scalability. In downstream manufacturing of AAV, tangential flow filtration (TFF) is an essential operation—usually performed at two steps in the process—that provides concentration, buffer exchange, and impurity reduction via ultrafiltration/diafiltration (UF/DF).

Filters that are reliable and provide process predictability help accelerate the path from development to commercialization. Part of the linearly scalable Pellicon® family of TFF filters, single-use Pellicon® Capsules and scale-down Pellicon® XL 50 cassettes provide reliability and reproducibility at any stage of your AAV process, from development to manufacturing.

Explore results of an evaluation of the scalability performance of Pellicon® Capsule and Pellicon® XL 50 cassette.