The Challenges Associated With CRISPR Gene Editing

Source: Cell & Gene

The introduction of the CRISPR technology and the ability to grow stem cells in the lab have been among the most important breakthroughs in the scientific world. CRISPR-engineered stem cell therapies have made tremendous advancements in the past 5 years, but challenges still exist. From understanding that CRISPR is in fact safe if used in the appropriate context to learning how CRISPR affords potential for immediate patient impact, there is no need to question the permanency of gene editing.

To learn more about CRISPR gene editing, Cell and Gene Chief Editor, Erin Harris, sat down with Sadik Kassim, Chief Technical Officer at Vor Biopharma to discuss the benefits of CRISPR-engineered stem cell therapies, the challenges and feasible solutions, what’s next, and more.

Off target effects — the field is developing new modalities that build on CRISPR to reduce off targeting effects. Develop less immunogenic or less inflammatory protein used to be able to enable direct infusion. There are many opportunities to address CRISPR challenges than ever before.

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