Newsletter | April 28, 2026

04.28.26 -- Target Selection Drives The Future Of CAR-T Therapy In Solid Tumors

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Webinar: A Novel Cell Selective Lentiviral Platform for in vivo CAR-T Engineering

Targeted lentiviral vectors are reshaping CAR-T manufacturing by enabling selective gene delivery to defined T-cell populations with greater speed and less complexity. In this webinar, Miltenyi Biotec explores a novel PV-pseudotyped LVV platform that supports efficient ex vivo and in vivo CAR-T generation, robust tumor cell depletion, and a promising path toward safer, scalable, and more accessible immunotherapies. Click here to learn more.

FOCUS ON MANUFACTURING

Target Selection Drives The Future Of CAR-T Therapy In Solid Tumors

Target selection is the defining challenge in CAR T therapy for solid tumors, shaping safety, efficacy, and the field’s path forward. Hear from clinical, translational, and scientific experts about the many perspectives to consider in target selection.

Scaling MSC Therapies: Overcome Cell Therapy Manufacturing Risks And Barriers

Achieve scalable MSC manufacturing by implementing closed systems and modular scale-out strategies that minimize contamination risks and ensure consistent cellular stability and efficacy.

Engineering Rep-Cap Plasmids To Enhance AAV Potency

Enhance AAV yield and quality through engineered Rep-Cap plasmids. This next-generation approach addresses core manufacturing hurdles to provide a more scalable solution for viral vector therapy.

Streamline Viral Vector Clarification Using TFDF

Tangential Flow Depth Filtration (TFDF) intensifies virus production by streamlining the clarification process. Boost efficiency and yield for both LV and AAV manufacturing with this methodology.

The Value Of Peptones For Cost-Effective Vaccine Manufacturing

Peptones address critical manufacturing challenges by boosting cell culture performance. Improve yields and lower overall production costs by integrating these components into your bioprocess.

Size Matters: Mastering Size Exclusion For Oligos

Learn how to separate molecules strictly by size, effectively remove salts, and select the correct pore specifications for a gentle, non-destructive purification workflow.

Wrap-Around Labeler Ideal Small Vials, Cartridges And Syringes

Discover a reliable solution for labeling small batches of medical products, including vials, syringes, and cartridges, that fully automatic machines struggle to handle.

Preserving hMSC Phenotypes In Stirred-Tank Bioreactors

Reach metabolic stability and consistent growth in cell therapy applications. Research highlights successful hADSC expansion using microcarriers within scalable stirred-tank bioreactors.

Combined Filtration For Mammalian Cell Clarification

Consolidate cell clearance and sterile filtration into a single device. This approach simplifies the clarification of CHO-cells and other mammalian cultures for more efficient downstream work.

Innovating Upstream Manufacturing For The Next Wave Of Gene Therapies

Explore a streamlined approach to transient AAV production, including yield improvements across serotypes, key transfection parameters, and practical guidance for scaling processes.

mRNA Vaccines And Therapeutics: Current Trends And Perspectives

Delve into the advancements and transformative impact of mRNA vaccine technology on modern medicine and see how this technology is revolutionizing healthcare for the future and beyond.

MANUFACTURING SOLUTIONS

A Better Way For Closed-System Processing In Cell Therapy - CPC

Stakeholder-Aligned Design For An Intuitive Manufacturing Process - Invetech

Innovating Upstream AAV Manufacturing For The Next Wave Of Gene Therapies - Mirus Bio

A Seismic Shift In Media And Buffer Consumption - Nucleus Biologics

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