TARGATT™ CHO Cells: Rapid, Stable CHO Cell Generation For Bioproduction
With our proprietary TARGATT™ technology for site-specific integration of large DNA fragments, we’ve developed a series of TARGATT™ “master” cell lines, including engineered CHO.
These cell lines are part of our user-friendly TARGATT™ Knock-In Kits, which you can use to knock in your GOI in your own lab. Using our TARGATT™ CHO cell lines and kits, stable CHO cells containing your gene of interest can be generated as fast as in two weeks. The TARGATT™ CHO can also be used for library construction and screening for new antibodies.
Why choose TARGATT™ CHO Cells?
Chinese Hamster Ovary (CHO) cells have emerged as a popular and versatile choice for biopharmaceutical production and research applications, offering several distinct advantages. Their adaptability to genetic engineering is exemplified by proprietary technologies like TARGATT™, which enables site-specific integration of large DNA fragments. This capability allows for the creation of “master” cell lines that can be easily manipulated to express genes of interest (GOI) with high efficiency. CHO cells are particularly valued for bioproduction of antibodies for example. Together with our TARGATT™ site-specific gene insertion technology, stable CHO cells containing a gene of interest can be generated within two weeks, offering a cost-effective and fast approach for bioproduction.
TARGATT™ CHO Master Cell Lines:
- Site-specific knock in into a high expression, safe harbor locus (H11)
- High efficiency integration >90% with drug selection
- Stable gene insertion intead of transient gene expresion
- BSL1 compatible
TARGATT™ CHO Library Kits
- Large cell library construction in CHO cells
- Development of a mammalian display system with a higher efficiency
- Provide a mammalian display system that can reach E. coli and yeast library sizes
