Tamping Pin Dosator To Fill Capsules For Early Phase Pharmaceutical Formulation
Part of 3P innovation’s Pharma Equipment Discover range, the tamping pin dosator fills capsules during early phase pharmaceutical formulation and automatically produces early phase clinical batches.
Increase laboratory capability and eliminate scale-up risk
A key advantage of this Tamping Pin Dosator is that the small size of the powder bowl actively supports process understanding at a stage when quantities of the active ingredient, available for process optimisation, can be extremely limited. This significantly reduces the cost of studies into compaction and dissolution.
This Tamping Pin Dosator is designed to fit on a bench or within a fume extraction environment and yet replicates full scale commercial processes. Scale-up issues are eliminated by the flexible design uses, wither 3P's or client's existing commercial pin sets (00 to 4).
It also operates with small amounts of active pharmaceutical ingredient, to match early stage formulation requirements. The system measures and records the force and position of each of the six tamping pins in real time together with dispensed weight to provide a "window" into the process. The ability to rapidly and cost effectively feedback representative process data into the formulation process significantly increase laboratory capability, adding value and eliminating risk.
Minimised process uncertainty
Specifically targeting capsule based formulations the Tamping Pin Dosator is designed to replicate a standard commercial process and can be used to screen formulations during the production cycle and before new powdered ingredients are run through existing production facilities.
Since the Tamping Pin Dosator records and permanently stores critical process parameters, quality benchmarks can be easily established against which reject criteria can be set. The ability to screen supplier products before issues are identified in-production can save significant equipment down time, removes uncertainties and strengthens in-house quality and supplier control procedures.
Post-process dosing parameters
The Tamping Pin Dosator is provided with data logging capabilities that provides users with details of the tamping pin displacement and compression forces associated with each stage of the powder slug's formation. The data files can be exported to a number of common packages, such that key process metrics can be established. The data is also presented graphically. Such data is critical during dissolution characterisation assessments.