Superior Performance Of SaniSure ® Pharm-A-Clear LH® Tubing In Extended Fill-Finish Applications

By Dr. Alex Van Hagen, Global Product Line Manager, Drug Product Filling, SaniSure®, and Nicholas Brust, Global Product Line Manager, Tubing, SaniSure

As biologics, cell therapies, and other complex injectable medicines drive demand for longer production campaigns, the performance of fill-finish consumables has become increasingly important. Tubing used in aseptic filling operations must maintain sterility, accuracy, and durability throughout extended manufacturing runs while minimizing the risk of contamination, downtime, and product loss.

A recent engineering study evaluated the operational lifespan of platinum-cured silicone tubing under simulated fill-finish conditions using peristaltic pump technology. The results highlighted how tubing design, dimensional consistency, and material performance can significantly influence fill counts, process efficiency, and overall manufacturing reliability. Extended tubing life can help reduce changeovers, lower contamination risks associated with manual interventions, and support the industry's ongoing shift toward continuous processing.

For biopharmaceutical manufacturers and CDMOs, understanding the relationship between tubing performance and operational outcomes is critical to optimizing aseptic filling operations. Explore the full white paper to learn how durable single-use components can contribute to greater productivity, improved process control, and reduced manufacturing risk in high-volume fill-finish environments.