Simplified Harvest And Media Exchange In Cell Therapy: Consistent, Compliant Scale-Up From Development To GMP

The transition from benchtop development to GMP manufacturing often exposes hidden vulnerabilities in process consistency. Conventional harvest methods like tangential flow filtration (TFF) and disc-stack centrifugation frequently struggle with parameter variability or high shear forces that compromise cell viability and product quality.

Maintaining critical quality attributes (CQAs) requires a shift toward low-shear, single-use systems designed for predictability. By utilizing technology that bridges the gap between scales, developers can simplify tech transfer and mitigate the risks associated with manual labor or engineering complexity.

This session explores case studies involving iPSC aggregates and MSCs, highlighting strategies to stabilize performance and shorten the path to the clinic. Watch the presentation to refine your scale-up strategy.