Separate Proteins, Peptides & Glycans Faster With BIOshell™ U/HPLC Columns With Fused-Core® Technology

As the pharmaceutical and biotechnology industries continuously evolve into the development of “large molecule” biotherapeutics to treat a myriad of diseases, both fast and high-resolution separations are required in order to resolve the numerous structural variants that exist in these complex samples.

The BIOshell™ line of superficially porous particle (SPP) packed columns has been developed to aid research into understanding the subtleties of the molecule that is being developed.

BIOshell™ columns enable fast and high-resolution separations to resolve the many structural variants that exist in samples of large biomolecules. Applications include:

• Top-down analysis of intact proteins, monoclonal antibodies (mAbs), and antibody-drug conjugates (ADC)
• Bottom-up analysis (peptide mapping) of proteins for primary structure confirmation
• Middle-up analysis of mAb fragments (light and heavy chains)
• High resolution separation of released N- and O-linked glycans.