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Learn what Organ-on-a-Chip technology is and why it’s setting the stage for the next generation of drug development and research. Organ-on-a-Chip technology is used by academia and the pharmaceutical industry across a wide variety of areas, including toxicology, immunology, gene therapy, and cancer research.
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Approximately 90% of drugs entering clinical trials will fail, with roughly 30% of failures attributed to unforeseen toxicity. Such abundant failure indicates that animal models alone are insufficient decision-making tools. The cost of this failure plays a central role in perpetuating the current productivity crisis — but Organ-Chips could help solve this issue.
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For centuries, the drug development industry has used preclinical models with insufficient predictive validity, meaning they inadequately predict how candidate drugs will affect humans. This is where Organ-on-a-Chip technology can make a big impact. Discover how Organ-Chips emulate human tissues and achieve better predictive validity.
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Having shown potential in treating blood cancers, CAR T-cell therapies are setting their sights on a more complex adversary: solid tumors. Learn what CAR T-cell therapy is, why solid tumors are such a challenging target, and how researchers can use advanced in vitro models to gain a more human-relevant understanding of CAR T efficacy.
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Researchers can unlock the full potential of organoids by using them as a robust cell source for Organ-Chips, enabling the creation of more accurate human biological models. Explore how combining organoids and Organ-Chips improves the organoids’ cellular morphology and functionality, which opens the door for new experimental designs, and more.
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