Sartorius Cell & Gene Tech Expo April 2026: Gene Therapy

Downstream processing for lentiviral vectors (LV) is often hindered by the inherent instability of the particles. Traditional purification methods can lead to significant losses in both yield and functional activity, as the vectors are highly sensitive to the physical and chemical stresses typically encountered during chromatography. Establishing a scalable, efficient process that maintains vector integrity is a primary goal for developers aiming to reduce manufacturing costs and accelerate clinical timelines.

In this presentation, Swapnil Choudhury from Sartorius introduces the Sartobind Convec D platform, a solution designed specifically to address the unique requirements of viral vector capture. The session explores how convective mass transfer and optimized membrane chemistry offer a more gentle alternative to conventional resin-based systems. By focusing on reducing processing time and utilizing mild operating conditions, this technology helps preserve the infectivity of fragile vectors while achieving high levels of purity.

The discussion covers the transition from small-scale process development to full-scale manufacturing, highlighting the importance of linear scalability and aseptic-compatible formats. Gain insights into how purpose-built chromatography tools can simplify the supply chain and improve the overall safety profile of the drug substance. Watch the full video to learn how advanced membrane technology is reshaping the landscape of LV purification.