Revealing Hidden Integration Events With TLA And Nanopore Sequencing
Source: Solvias
A biotechnology company developing a recombinant protein-producing CHO cell line needed to confirm that a new genetic construct had integrated only at the intended landing pad, and that no hidden structural rearrangements had occurred. Conventional confirmation methods couldn't provide the complete picture.
Our combined Target Locus Amplification (TLA) and Nanopore sequencing approach delivered:
- Precise confirmation of the intended integration site
- Detection of unexpected structural rearrangements within the inserted construct
- Comprehensive characterization by combining genomic localization with long-read structural reconstruction
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