PRIME-XV T Cell CDM: Chemically Defined, Animal Component-Free Medium For T Cell Culture

PRIME-XV T Cell CDM is a chemically defined, animal component-free medium designed to support robust expansion and transduction of human T cells. It enables consistent growth and high viability across both static and dynamic culture systems, outperforming traditional FBS-supplemented and xeno-free media. The formulation supports both CD4⁺ and CD8⁺ subsets, maintains functional markers, and facilitates efficient lentiviral transduction without the need for enhancers or spinoculation. Data from multiple donors demonstrate reliable cell viability and expansion, even under GMP conditions using CTGrade rh IL-2 proteins. With proven scalability and regulatory alignment, this medium is positioned to streamline the transition from research to clinical manufacturing.

For researchers seeking consistency and performance in T cell culture, discover how this solution offers a compelling alternative to serum-based methods.