Application Note

Primary Clarification Of Lentiviral Vector With Low-Shear Separation


Lentiviral vectors are sensitive to the shear forces of traditional continuous centrifugation systems. Among the key challenges of supernatant clarification for downstream processing of lentiviral vectors are low titer recovery and loss of the vector’s activity.

View data that demonstrates the performance of the UniFuge® cell harvesting system for the clarification of lentiviral vectors. Key performance indicators including viral titer recovery and turbidity are presented for a range of conditions including batch size, cell viability, and feed rate.

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