XT-Thrive® is a DMSO-free, serum-free, protein-free, and chemically defined cryopreservation media for the preservation of mammalian cells at ultra-low temperatures (-70° C to -196° C). Designed and manufactured with the utmost quality in mind, XT-Thrive® is tailored to provide high cell recovery and functionality. It is a non-toxic & hyper-effective alternative to traditional cryopreservatives and is plug and play for cell & tissue manufacturing processes.
- Cryopreservation is a crucial part of manufacturing regenerative medicines
- Existing standards in cryopreservation use 5-10% dimethyl sulfoxide (DMSO) and often serum or serum albumin
- These products have not been significantly improved for over 50 years
- DMSO exhibits toxicity in patients and causes adverse cell mutations at low doses (0.1%)
XT-Thrive® enables non-toxic cryopreservation for life-saving regenerative medicines such as vaccines, cell & gene therapies, and engineered tissues.
Benefits of XT-Thrive®
DMSO-FREE AND NON-TOXIC
XT-Thrive® is a non-toxic and non-genotoxic cryopreservation solution that reduces the risks of adverse alterations in cellular phenotype during preservation and clinical side effects during and after cell therapy.
XT-Thrive® is a fully chemically defined formulation and contains no serum or recombinant proteins.
XT-Thrive® doesn‘t compromise on performance despite lacking DMSO. It is designed to preserve the viability, physical integrity, and ultimately the functionality of cells post-thaw after storage at -70° C or in liquid nitrogen.
OPTIMIZED PROCESS FOR SCALE
XT-Thrive® enables a significant extension in the allowable timeframe for pre-freeze and post-thaw incubation. And unlike DMSO, no wash-out is required.
PLUG AND PLAY INTEGRATION
XT-Thrive® is extremely process-friendly and can be directly plugged into current workflows without requiring specialized instrumentation. It can directly replace the cryopreservation solutions that contains DMSO and/or serum.
Fields of Application of XT-Thrive®
XT-Thrive® has been validated by third parties in the following key therapeutic cells.
Cryopreservation Solution for Mammalian Cell Lines
HEK293, Jurkat, K562, TF-1, HL-1, HEPG-2, CHO, U2OS
Cryopreservation Solution for Mammalian Primary Cells
PBMCs, T Cells, CAR-T Cells, B Cells
iPSCs, iPSC-derived cardiomyocytes
BM and BM-derived HSCs and MSCs
Cord Blood and Cord blood-derived HSCs and MScs
Cryopreservation Solution for Tissues
Full-thickness skin grafts