Performance Comparison Of The Vericheck ddPCR™ Empty-Full Capsid Kit And Analytical Ultracentrifugation (AUC)

Ensuring the presence of the intended vector genome in adeno-associated virus (AAV) capsids is critical for their therapeutic effect. Current biophysical methods, such as analytical ultracentrifugation (AUC), treat all DNA within a capsid as equivalent, failing to identify problematic contaminant DNA. This application note delves into the precision of the Vericheck ddPCR Empty-Full Capsid Kit, which excels at measuring only the intended vector genome.

This capability provides a stronger correlation with overall product quality and safety, addressing a significant challenge in gene therapy manufacturing. To learn more about this innovative approach and its benefits, download the application note.