Application Note

Organic-Phase Encapsulation In Protein-Based Nanocapsules Studied By DLS

Source: Wyatt Technology

By Claudia Tallian, Robert Vielnascher, and Georg M. Gübitz

WYATT DynaPro NanoStar

Protein-based nanocapsules composed of human serum albumin and silk fibroin (Bombyx mori) were investigated for particle size using dynamic light scattering (DLS), hence proving ultrasound-induced crosslinking and the successful production of monodisperse HSA-SF nanocapsules.

In this study, dispersion properties, such as dispersion stability, agglomeration and temperature stability based on particle size analysis are investigated. Dissect dispersion behaviors that serve as a basis for further experiments and lead to the successful separation of a stable dispersion of nanocapsules.

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Wyatt Technology