Nuvia wPrime 2A Hydrophobic Weak Anion Exchange Resin

Nuvia wPrime 2A Resin is a mixed-mode chromatography solution combining hydrophobic interaction and weak anion exchange to deliver high purity and recovery of challenging biomolecules. Its adjustable charge state enables selective binding of impurities like aggregates, viruses, and nucleic acids, while allowing therapeutic proteins and monoclonal antibodies to flow through. Designed for scalability and robustness, the resin maintains consistent dynamic binding capacity even at high flow rates and after repeated cleaning cycles. With excellent pressure-flow properties and straightforward method development, it supports efficient downstream purification across a wide range of conditions. Whether optimizing for monomer recovery or impurity clearance, this resin offers a reliable platform for both established and emerging biotherapeutics.

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