NK Cell Expansion Using Scale Up Bioreactors For Cell Therapy

As part of the innate immune response, Natural Killer (NK) cells can provide an anticancer response in an antigen-independent manner. This characteristic makes them a promising candidate for "off-the-shelf" allogeneic therapeutic products. However, a key challenge in the cell and gene therapy industry is the ability to expand and process NK cells using regulation-compliant reagents and closed manufacturing systems.

This poster details a feeder-free NK cell expansion medium that can expand human primary enriched NK cells to clinically relevant levels. The expanded cells maintain their functionality and phenotype, demonstrating their ability to kill cancer cells in vitro and control tumor burden in vivo. Access the poster to learn more about the feeder-free medium and a closed-system cell processing solution that enables the expansion and processing of clinically relevant numbers of functionally viable NK cells.