mRNA Manufacturing Workflow: A Flexible Approach To Get To Clinic And Market Faster

Like many therapeutic manufacturing workflows, every step in the mRNA process builds upon the prior step. Plasmids are critical starting materials used for mRNA synthesis, after which the resulting purified mRNA is encapsulated for more efficient stability and delivery. The encapsulated final drug product must then be sterile-filled, packaged, labeled, and shipped to its final clinical destination. Additionally, in-process and final release testing are critical to ensure robust Chemistry, Manufacturing, and Controls (CMC). As the manufacturing process progresses, every step adds complexity and cost, so it’s important to ensure steps are compatible and integrated into each other.

This infographic explores each intertwined step in the mRNA manufacturing process and outlines how Thermo Fisher Scientific’s flexible approach can get your mRNA product to clinic and market faster.