Moving Beyond Gut Feel In Cell Therapy Design With AI And Synthetic Biology

In this opening segment of Cell & Gene Live, "Building Smarter Cell Therapies with AI and Synthetic Biology," Senti Biosciences' Tim Lu, M.D., Ph.D., and Claire Aldridge, Ph.D. explained that the complexity of cells requires moving beyond single gene intuition to large-scale design–build–test of gene circuits. They covered where synthetic biology generates rich datasets and AI helps map design space and optimize sophisticated, decision making cell therapies. They covered why leadership teams still over-rely on gut feel and legacy plasmid designs and should instead use computational models to systematically explore promoters and control elements so therapies are not just functional but truly optimized.