Product/Service

Custom And High Throughput Media Development

Source: OmniaBio

We work collaboratively with clients to develop and optimize custom media to enable process development and cGMP scale-up of cell and gene therapies.

  • CCRM's custom liquid handling robotics system, with integrated tissue culture incubator and advanced plate reader analytics, paired with a UHPLC-MS and high-throughput flow cytometry provides one of a kind automation and high-throughput options for media development.
  • DoE-based, HTS approach for custom media development and optimization (1000s-10000s of unique formulations screened in parallel); allowing for multi-variate statistical analysis and model fitting to map design space.
  • Workflows include discovery and targeted metabolomics and proteomics, growth rate screening of adherent and suspension-based cell cultures, and high-throughput flow cytometry for marker discrimination. These have been used for removal of animal components, optimization of growth rates, and optimization of multi-stage differentiation protocols.