Product/Service

MabSelect™ VH3 Affinity Resin

Source: Cytiva
Antibodies And Proteins GettyImages-1364886992

Improve efficiency in capture of antibody variants

MabSelect™ VH3 affinity resin uses an engineered protein A ligand that interacts only with the variable heavy chain of the VH3 sequence family of the human antibody. The traditional protein A interaction with the antibody’s fragment crystallizable (Fc) region is knocked out to allow efficient separation of bispecific antibody (bsAb) and antibody fragments.

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MabSelect VH3 affinity resin uses an engineered protein A resin that interacts only with the variable heavy chain containing the VH3 sequence family. The traditional Fc interaction is removed.

  • High binding capacity for antibody fragments and enhanced binding for bispecific antibodies containing VH3 sequence family.
  • High alkaline stability – stable when cleaned with 0.5 M NaOH, reducing risk for bioburden incidents and providing long resins life time.
  • Provides good resolution for product-related impurities in the capture of asymmetric bispecific antibodies with VH3 sequence family on one arm.

Cytiva