MabSelect™ VH3 Affinity Resin
Source: Cytiva

Improve efficiency in capture of antibody variants
MabSelect™ VH3 affinity resin uses an engineered protein A ligand that interacts only with the variable heavy chain of the VH3 sequence family of the human antibody. The traditional protein A interaction with the antibody’s fragment crystallizable (Fc) region is knocked out to allow efficient separation of bispecific antibody (bsAb) and antibody fragments.
MabSelect VH3 affinity resin uses an engineered protein A resin that interacts only with the variable heavy chain containing the VH3 sequence family. The traditional Fc interaction is removed.
- High binding capacity for antibody fragments and enhanced binding for bispecific antibodies containing VH3 sequence family.
- High alkaline stability – stable when cleaned with 0.5 M NaOH, reducing risk for bioburden incidents and providing long resins life time.
- Provides good resolution for product-related impurities in the capture of asymmetric bispecific antibodies with VH3 sequence family on one arm.
Cytiva
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