Chapter Five: Key Requirements For Efficient And Linear Scale-Up Of Shear Sensitive Cell Therapy Products Using The Vertical-Wheel Bioreactor

In the fifth and final chapter of this webinar series, explore the intricate challenges of developing and scaling manufacturing processes for shear-sensitive cell therapy products. These include selecting bioreactors with appropriate hydrodynamics for specific cell types and managing complex operations like large-scale medium exchange and gassing, which often make bioreactor-based processes appear non-linear. Despite these hurdles, the speaker demonstrated that scalable solutions exist. By choosing a versatile bioreactor—such as the vertical wheel model with scalable hydrodynamics—and implementing robust c-train processes, perfusion-based medium exchange, and innovative gassing strategies, teams can achieve successful and linear scale-up.

If you're working on cell therapy manufacturing, now is the time to explore these scalable solutions and take the next step toward optimizing your process.