iPSC Gene Editing Services

Move confidently with precision engineering and iPSC expertise

At Applied StemCell, we don’t just offer gene editing services, we specialize in editing iPSCs with the precision, consistency, and technical depth your project demands.

Our team brings years of experience in iPSC handling and gene editing, ensuring high viability, low off-target risk, and reproducible outcomes.

Whether you’re engineering a screening line, creating a disease model, or developing a therapeutic candidate, we match the iPSC genome editing technology to your project goals:

• CRISPR/Cas9 for point mutations and knock-outs
• Mad7, a Cas12a-like nuclease, for product development
• TARGATT technology for highly efficient, site-specific large DNA knock-ins

With Applied StemCell, you have a partner who understands the complexity of iPSC gene editing and delivers results you can build on.

500+ Unique iPSC lines successfully developed

>98% Projects completed to customer specifications

1,000+ Gene editing projects completed

Our iPSC gene editing service

We support your project from start to finish, whether you only need iPSC gene editing or would like a complete iPSC workflow from reprogramming to differentiation.

1. Your service begins before you even sign a quote, by meeting with our technical team to understand your project goals and develop a project strategy.
2. After your quote is signed, we’ll have a kick-off meeting where we verify project objectives, tasks, and timelines.
3. We can start with an iPSC line you provide, one of our in-house iPSC lines, such as our our ActiCells™ GMP hiPSCs, or custom reprogram an iPSC line for you.
4. During the editing process—which is conducted from start to finish in our California facilities—we keep you updated on project status and are fully transparent about any challenges that arise.
5. We maintain pluripotency maintained throughout the genome editing process using high-end cell culture reagents and optimized protocols
6. Once the iPSC gene editing is complete, we perform rigorous QC analyses to confirm the gene edit(s) and clonal stability. We can also run additional characterizations such as to confirm pluripotency.
7. We can continue your project by differentiating your edited iPSCs into your desired cell type.

As with all of our iPSC services, we can perform your iPSC gene editing service under cGMP-compliant conditions—learn more about our GMP services.