In Vitro Glycoengineering (IVGE): Taking Control Of Glycosylation

The complexity of upstream bioprocessing means that numerous input variables can affect the final quality of a therapeutic protein, especially its glycosylation profile. This often creates a narrow operational window, forcing developers to balance yield, purity, and getting the right glycoform. In vitro glycoengineering (IVGE) expands this window by shifting glycosylation control to the downstream process. This allows upstream processes to be optimized for yield and purity, while the desired glycopattern is reliably achieved later. IVGE is robust, scalable, and can be integrated efficiently after the initial purification step.

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